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CircRNA Synthesis
- Product Introduction
With greater stability attributed to its unique closed-loop structure, circRNA is an ideal platform for the development of next-generation gene therapy as an effective alternative to linear mRNA. Geneseed has original circularization patent technology, which can realize high efficiency circularization of RNA, and the prepared circRNA has high integrity and purity, as well as strong translation and expression ability, which can be used in many fields such as cell transfection, animal experiments, and drug efficacy evaluation.
Technology Platform
circRNA sequence design platform
circRNA production and preparation platform
circRNA purification platform
circRNA quality control platform
Technical FeaturesPatent protection: two original patent circularization technologies, fully matching customer needs;High circularization efficiency: circularization efficiency up to 90% and above;High product purity: purity up to 90% and above;Strong translation and expression: after transfecting cells, the protein expression effect is stronger than mRNA;Rigorous quality control: multi-dimensional quality control evaluation to meet the needs of each stage;Multiple choices: provide personalized customized services and catalog products.Two core independent intellectual property rights
Fig. 1: Strategy for customization circRNA of GeneseedWorkflow of CircRNA Production
Structural Analysis and Sequence Design → Gene Synthesis to Plasmid Preparation → DNA Template Preparation →Transcription and Circularization → CircRNA Purification → Quality Control
Our Service
You offer: sequence information, preparation requirements
We provide: preparation products, quality control results, experimental reports, reference methods for cell transfection and animal experiments, etc.
Case Studies
1、Circularization efficiency can reach more than 90%.
2、The integrity (CE) of circRNA after purification > 95%
3、The purity of circRNA after purification (HPLC) > 95%
4、CircRNA shows higher expression vs mRNA
Related Products-Catalog circRNA
Catalog circRNA can be used as positive controls for experimental exploration in the areas of translation expression validation, transfection delivery assessment, and process optimization
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